How the Menstrual Cycle Changes Women’s Brains

Lately there’s been a lot of talk about brain fog. Brain fog, or mental clouds, it’s when  you feel out of it. When you are more forgetful than usual, and when you have a lack of  mental clarity. Brain fog is when you don’t feel like you. There’s a lot of people with  COVID and the after effects of the virus experiencing brain fog. Before the pandemic, no  one really talked about brain fog, or mental fatigue, it wasn’t in the common vocabulary.  

But did you know that during our periods we can often experience brain fog? 

On our periods, we feel out of it, we don’t feel like our whole selves, but this is because  of what is happening to our brains during this point of our menstrual cycles. And part of  this has to do with the sugar and fat cravings we all experience before our periods; I  know I certainly would do anything for chocolate! 

In Scientific studies during PMS, women with severe PMS mood symptoms send much  larger amounts of glucose (sugar levels) to a specific area of the brain, the cerebellum. 

If there is not enough glucose (those sugar energy levels), the cerebellum can’t properly  perform important functions like mood regulation, managing fear, pleasure responses and  motor control. This leads to the four core mood symptoms of PMS: anxiety, gloominess,  stress and irritability; and this is also when you might experience brain fog. Maybe  you’ve even experienced being “hangry,” when you need to eat, it’s the stress and anxiety  of not getting the proper nutrients to your cerebellum causing these shifts to your brain! 

Your body and brain crave sugar levels during PMS.  

When you need those carbs or a piece of chocolate, immediately, it’s your brain craving  sugar levels to try and regulate your mood. Chocolate, cookies, or ice cream might  provide some short-term relief from those PMS mood swings like brain fog, anxiety, and  stress, but then you get the sugar crash! 

But because of the way we metabolically process sugar in these high carb foods, the  short-term improvements are quickly lost as we crash leaving the cerebellum with less  energy (and more brain fog, anxiety, gloominess, stress, and irritation) and making us  feel worse than before. And maybe guilty by how much chocolate we were able to eat, I  know I’ve been there. 

So what does this mean for our brains? 

In recent studies, an ingredient from part of the Krebs cycle has been shown to work in  the liver to support the process of turning fatty acids into glucose so that the sugar energy  is readily available for the cerebellum when it needs it most. This ingredient is called  oxaloacetate, already found in almost every cell of your body, and by supplementing with  oxaloacetate, it translates to a well-fed cerebellum, and so fewer mood wings in clinical  trials.

Oxaloacetate may be the superpower supplement to fight PMS and Brain Fog! 

There are of course other factors that make us feel off-kilter and foggy during PMS.  Neurotransmitter imbalances make PMS even worse! 

Two neurotransmitters, GABA and glutamate are always in a balancing act in the brain.  During the part of the month when you’re not PMS-ing, the GABA/Glutamate ratio in  your brain is level and keeps you feeling like your regular self, but before your period,  hormonal shifts can knock these two neurotransmitters out of balance. 

When glutamate levels are too high and GABA levels are too low, something that  normally wouldn’t bother you feels like the world is crashing down on your shoulders.  Excessive glutamate putting your brain on overdrive, every PMS symptom feels even  WORSE! 

So how does an Oxaloacetate Supplement for PMS fit in with these  Neurotransmitters? 

Oxaloacetate mechanistically reduces excess glutamate levels, and increases GABA  levels which may help you to feel like yourself again. 

As the oxaloacetate reduces your excess glutamate levels, it brings your GABA and  glutamate levels back into balance so you can feel like yourself again, reducing those  feelings of stress, anxiety, and brain fog during PMS. 

How do I find this Oxaloacetate Supplement for PMS? 

Currently, there’s only one supplement for PMS made with oxaloacetate on the market,  it’s called Jubilance for PMS. In gold-standard peer-reviewed clinical trials, women who  took oxaloacetate daily for just one month experienced an over 50% reduction in their  PMS symptoms. 

PMS and Brain fog all come down to the sugar levels present in your brain, so now that  there’s a way to regulate them, you don’t need to feel bad anymore during that time of the  month! Jubilance for PMS, the oxaloacetate supplement for PMS is the solution to this  problem that we’ve been waiting for. Why not give Jubilance a try, in fact they offer a  money-back guarantee if you don’t see improvement. Learn more at


  1. Liu B, Wang G, Gao D, Gao F, Zhao B, Qiao M, et al. Alterations of GABA and glutamate-glutamine levels in premenstrual dysphoric disorder: a 3T proton magnetic resonance spectroscopy study. Psychiatry Res. 2015;231(1):64-70.
  2. Michener W, Rozin P, Freeman E, Gale L. The role of low progesterone and tension as triggers of perimenstrual chocolate and sweets craving: some negative experimental evidence. Physiol Behav. 1999;67(3):417-20. 
  3. Mantantzis K, Schlaghecken F, Sunram-Lea SI, Maylor EA. Sugar rush or sugar crash? A meta-analysis of carbohydrate effects on mood. Neurosci Biobehav Rev. 2019;101:45- 67. 
  4. Marco R, Pestana A, Sebastian J, Sols A. Oxaloacetate metabolic crossroads in liver. Enzyme compartmentation and regulation of gluconeogenesis. Mol Cell Biochem. 1974;3(1):53-70. 
  5. Tully L, Humiston J, Cash A. Oxaloacetate reduces emotional symptoms in premenstrual syndrome (PMS): results of a placebo-controlled, cross-over clinical trial. Obstet Gynecol Sci. 2020;63(2):195-204. 
  6. Bixo M, Ekberg K, Poromaa IS, Hirschberg AL, Jonasson AF, Andreen L, et al. Treatment of premenstrual dysphoric disorder with the GABAA receptor modulating steroid antagonist Sepranolone (UC1010)-A randomized controlled trial.  Psychoneuroendocrinology. 2017;80:46-55. 
  7. Femenia T, Gomez-Galan M, Lindskog M, Magara S. Dysfunctional hippocampal activity affects emotion and cognition in mood disorders. Brain Res. 2012;1476:58-70. 
  8. Li Y, Hou X, Qi Q, Wang L, Luo L, Yang S, et al. Scavenging of blood glutamate for enhancing brain-to-blood glutamate efflux. Mol Med Rep. 2014;9(1):305-10. 
  9. Wilkins HM, Harris JL, Carl SM, E L, Lu J, Eva Selfridge J, et al. Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. Hum Mol Genet. 2014;23(24):6528-41. 
  10. Bannister E. There is increasing evidence to suggest that brain inflammation could play a key role in the aetiology of psychiatric illness. Could inflammation be a cause of the premenstrual syndromes PMS and PMDD? Post Reprod Health. 2019;25(3):157-61.